DanceTherParkinsonV1, Main, Exploration, bibRecord, 000218

Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease

Identifieur interne : 000218 ( Main/Exploration ); précédent : 000217; suivant : 000219

Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease

Auteurs : Yi Guo [République populaire de Chine] ; Wei-Dong Le [États-Unis] ; Joseph Jankovic [États-Unis] ; Hua-Rong Yang [République populaire de Chine] ; Hong-Bo Xu [République populaire de Chine] ; Wen-Jie Xie [États-Unis] ; Zhi Song [République populaire de Chine] ; Hao Deng [République populaire de Chine, États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2011-08-01.

RBID : ISTEX:5BD9FFB534DB04A6CC579625402D89203B8CD18E

English descriptors

KwdEn :
- Parkinson disease, paired‐like homodomain transcription factor 3, susceptibility, transcription factor.

Abstract

Paired‐like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.

To determine whether genetic variation in the coding region of the paired‐like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.

We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early‐onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society

Url:

https://api.istex.fr/document/5BD9FFB534DB04A6CC579625402D89203B8CD18E/fulltext/pdf

DOI: 10.1002/mds.23693

Affiliations:

Links toward previous steps (curation, corpus...)

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to stream Istex, to step Curation: 000097
to stream Istex, to step Checkpoint: 000051
to stream Main, to step Merge: 000218
to stream Main, to step Curation: 000218

Le document en format XML

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<front><div type="abstract">Paired‐like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons.</div>
<div type="abstract">To determine whether genetic variation in the coding region of the paired‐like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease.</div>
<div type="abstract">We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early‐onset Parkinson's disease and familial Parkinson's disease. © 2011 Movement Disorder Society</div>
</front>
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	Danse-thérapie et Parkinson
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Danse-thérapie et Parkinson

Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease

Systematic genetic analysis of the PITX3 gene in patients with Parkinson disease

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri